RISK TRANSMISSION AND CONTROL OF PORT-HINTERLAND SERVICE NETWORK: FROM THE PERSPECTIVE OF PREVENTIVE INVESTMENT AND GOVERNMENT SUBSIDIES

The increase in risk prevention investments in the port-hinterland service network (PHSN) effectively enhances the network’s ability to resist risks and improve the sustainability and stability of ocean transportation. Based on the construction of the PHSN risk prevention investment utility model, the equilibrium strategy, the related characteristics of each participant in the complementary networks and the complete network are analyzed. Similarly, the subsidy policy of the government under the utility maximization of the whole service network is studied. We further propose new types of subsidy strategies based on the key nodes and key groups given the resources available and the subsidy efficiency constraints imposed, while also validating the advantages of this method based on a case analysis. The results indicate that the (1) equilibrium risk prevention investment is closely related to the Katz-Bonacich centrality, network interaction intensity, cost of unit risk prevention investment and competition intensity; (2) an undifferentiated subsidy strategy cannot improve the risk prevention effectiveness of the whole network; (3) the subsidy strategy based on key nodes and key groups effectively improves the risk prevention efficiency; and (4) the subsidy strategy of key groups is superior to the subsidy strategy of key nodes. Accordingly, the results of this study provide a reference for participants and managers in the PHSN when making risk prevention investment decisions

Fully Bayesian Analysis of Relevance Vector Machine Classification With Probit Link Function for Imbalanced Data Problem

The original RVM classification model uses the logistic link function to build the likelihood function making the model hard to be conducted since the posterior of the weight parameter has no closed-form solution. This article proposes the probit link function approach instead of the logistic one for the likelihood function in the RVM classification model, namely PRVM (RVM with the probit link function). We show that the posterior of the weight parameter in PRVM follows the Multivariate Normal distribution and achieves a closed-form solution. A latent variable is needed in our algorithms to simplify the Bayesian computation greatly, and its conditional posterior follows a truncated Normal distribution. Compared with the original RVM classification model, our proposed one is a Fully Bayesian approach, and it has a more efficient computation process. For the prior structure, we first consider the Normal-Gamma independent prior to propose a Generic Bayesian PRVM algorithm. Furthermore, the Fully Bayesian PRVM algorithm with a hierarchical hyperprior structure is proposed, which improves the classification performance, especially in the imbalanced data problem

Evolution of spatial and temporal patterns of railway container transportation: A case study of China cities

The healthy development of railway container transport is an important part of railway freight transport and is key for promoting the green transformation of China's transport and supporting a new pattern of transport development. In this study, railway container handling station (RCHS) data, kernel density analysis, standard deviation ellipse, Herfindahl–Hirschman index (HHI), trend surface analysis (TSA), and R index were applied to examine the evolution characteristics of container transport patterns after the market-oriented reform of China's railway freight transport in 2013. The results are as follows: First, the overall scale growth trend is obvious, and the double-center effect of transport scale on the Bohai Rim region and Chengdu–Chongqing Economic Zone is evident, with the transport center of gravity moving northward. Second, the amount of attraction/occurrence is consistent in spatial distribution, and the aggregation effect of both is similar, essentially exhibiting a tendency of being high in the northwest and low in the southeast. Third, the pattern of “export-oriented in the north and import-oriented in the south” has taken shape; nearly half of cities in China have stable traffic functions, stable traffic supply, and demand relationships, and the change of functions shows that the industrial structure is constantly upgrading. This study elucidates the pattern of railway container transport in cities in China and provides empirical guidance for adjusting the functions of urban freight transport, thereby promoting the healthy development of urban freight transport and optimizing urban transport planning

A Comprehensive Review of One-Dimensional Metal-Oxide Nanostructure Photodetectors

One-dimensional (1D) metal-oxide nanostructures are ideal systems for exploring a large number of novel phenomena at the nanoscale and investigating size and dimensionality dependence of nanostructure properties for potential applications. The construction and integration of photodetectors or optical switches based on such nanostructures with tailored geometries have rapidly advanced in recent years. Active 1D nanostructure photodetector elements can be configured either as resistors whose conductions are altered by a charge-transfer process or as field-effect transistors (FET) whose properties can be controlled by applying appropriate potentials onto the gates. Functionalizing the structure surfaces offers another avenue for expanding the sensor capabilities. This article provides a comprehensive review on the state-of-the-art research activities in the photodetector field. It mainly focuses on the metal oxide 1D nanostructures such as ZnO, SnO2, Cu2O, Ga2O3, Fe2O3, In2O3, CdO, CeO2, and their photoresponses. The review begins with a survey of quasi 1D metal-oxide semiconductor nanostructures and the photodetector principle, then shows the recent progresses on several kinds of important metal-oxide nanostructures and their photoresponses and briefly presents some additional prospective metal-oxide 1D nanomaterials. Finally, the review is concluded with some perspectives and outlook on the future developments in this area

MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy. The understanding of its gene expression regulation and molecular mechanisms still remains elusive. Started from experimentally verified T-ALL-related miRNAs and genes, we obtained 120 feed-forward loops (FFLs) among T-ALL-related genes, miRNAs and TFs through combining target prediction. Afterwards, a T-ALL miRNA and TF co-regulatory network was constructed, and its significance was tested by statistical methods. Four miRNAs in the miR-17–92 cluster and four important genes (CYLD, HOXA9, BCL2L11 and RUNX1) were found as hubs in the network. Particularly, we found that miR-19 was highly expressed in T-ALL patients and cell lines. Ectopic expression of miR-19 represses CYLD expression, while miR-19 inhibitor treatment induces CYLD protein expression and decreases NF-κB expression in the downstream signaling pathway. Thus, miR-19, CYLD and NF-κB form a regulatory FFL, which provides new clues for sustained activation of NF-κB in T-ALL. Taken together, we provided the first miRNA-TF co-regulatory network in T-ALL and proposed a model to demonstrate the roles of miR-19 and CYLD in the T-cell leukemogenesis. This study may provide potential therapeutic targets for T-ALL and shed light on combining bioinformatics with experiments in the research of complex diseases

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Design of Evaluation Scheme for Social Responsibility of China’s Transportation Enterprises from the Perspective of Green Supply Chain Management

Corporate social responsibility (CSR) in the supply chain has become an increasingly popular research topic, but there are little researches on developing countries or emerging market economies as the research object, let alone providing a framework for assessing CSR in sustainable supply chains in the context of these countries. This paper will make up for these literature gaps. From the perspective of the green supply chain management, this paper integrates various authoritative standards and adopts two methods, “R clustering” and “variation coefficient analysis”, to establish a CSR performance evaluation system of China’s transportation industry. Applying the mean square error index weighting method analyzes the performance of 74 companies in China’s transportation industry in 2018 to verify the rationality of the evaluation system. The results find that this industry generally scores low and the performance of responsibilities of different sub-sectors in this industry is different, but the overall performance trend is improving. This research has implications for China’s transportation industry to improve CSR levels from the perspective of green supply chain management, for managers and stakeholders who are committed to improving China’s CSR green and sustainable development, and for the development of CSR in developing countries and emerging markets

Optimization on Loan-to-value Ratios of Port’s Inventory Financing: Effects of Risk Aversion and Decision Preference

Under inventory financing mode, port offers joint logistics and financial services to a capital-constrained cargo-owner whose cargos are taken as collaterals. Port takes financial risk while gaining profit from both traditional logistics and derived financial services. This paper adopts Mean-CVaR criterion to formulate objective function and derive the equilibrium loan-to-value ratio. The Mean-CVaR model proposed in this article depicts risk-aversion attitude and decision preference of port under the uncertainty of collateral’s demand. The result shows that there is a positive relation between decision preference and loan-to-value ratio. The growth in risk aversion attitude prompts port to act cautiously by reducing the loan-to-value ratio

Carbon Mitigation Strategies of Port Selection and Multimodal Transport Operations—A Case Study of Northeast China

In the last few decades, the progression of climate change has made people aware of the need to reduce CO2 emissions. In this study, the effect of this awareness on container transport in Northeast China is used as an empirical case study. Firstly, we propose that the freight demand index, calculated by the entropy weight TOPSIS (technique for order preference by similarity to an ideal solution) method, reflects the degree of container demand in destination cities. Then, we describe five scenarios against the background of China&rsquo;s container development plan and use them to evaluate the cost and carbon emissions of container rerouting. The overall objective of the study is to assess the effects of changes in port selection on the formation of new routes and multimodal transport. The results show that carbon taxes do not significantly affect multimodal transport networks, and the impact of loading and unloading costs on the total cost is far greater than that of corresponding carbon emissions. Despite the railway transportation capacity of Dalian Port, the results show that Yingkou Port and Dandong Port will expand by 227.8% and 191.4% over 2017, respectively. Therefore, Liaoning Port Group needs to reposition its different ports